An agent-based model of the Notch signaling pathway elucidates three levels of complexity in the determination of developmental patterning

Table 3 Results of Feedback experiments

Experiment	Outcome
Nn turns up N transcription and turns down Dl transcription	Good stability and pattern across a wide set of parameters
Nn turns up N transcription only	Model crashes with 0 neuron count and fails to oscillate
Nn turns down Dl transcription only	Low neuron and rosette count (< 5), no oscillating runs that stabilize
No feedback	Model crashes with 0 neuron count and fails to oscillate

ISSN: 1752-0509